Precision nutrition tailored strategies based on adequate vitamin D supplementation during pre- and peri-conception periods could largely improve vitamin D deficiencies in both women and babies, potentially associated with immunological benefits and musculoskeletal health. On the other hand, a genome-wide association study across 7 million single nucleotide polymorphisms in Asian populations of Malay, Indian, and Chinese women, revealed that genetic variation (rs4588) in GC gene encoding for vitamin D binding protein was associated with low vitamin D status in mothers and cord blood, while the variation in CYP2J2 (rs10789082) was associated with low vitamin D in the antenatal analysis only ( Sampathkumar et al.). The results have been demonstrated in women of African descent and warrant more research in the race- and ethnic-specific context. Thus, it has been suggested that a genetic variation in SLC5A5 (rs775249401) gene locus might modulate transportation of iodine into breast milk, with A-allele carrier mothers being more efficient with iodine transportation to breast milk when exposed to inadequate iodine intake ( Siro et al.). In addition to the nutritional intake itself, a genetic make-up might modulate mother-offspring nutritional transfer. The first 1,000 days concept requires appropriate delivery of essential nutrients, otherwise, a set of metabolic derangements may occur in malnourished children ( 3). Microelements and Bioactives in Early Life Development and Healthy AgingĮarly development largely depends on maternal nutritional competence, which primarily relies on intake but could also be modulated by endogenous factors such as the genetic background of a mother and even the developing fetus, both factors influencing the adequate nutritional supply of an offspring. Having said that, this Research Topic reflects recent works dealing with nutrigenetic and gene x dietary/environment interactions, micronutrients, and microbiota responsiveness to bioactive supplementation, altogether evaluated in various health contexts. Huge interest, however, remains in supplying adequate amounts of essential microelements, individual nutrients, and bioactives, based on personal predispositions which include genetics, microbiota features, and molecular nutrition biomarker profiles. Some endeavors have been made to customize macronutrient intake for individual predispositions, through the implementation of different dietary regimes, such as the Mediterranean diet with optimized fat intake ( 1), or a keto diet that favors fat intake ( 2). Precision nutrition aims to translate individual molecular signatures into applicable personalized dietary and nutritional recommendations and ultimately a personalized dietary plan. The importance of precision nutrition in health management strategies is gaining attention.
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